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Connecting the αα-hubs: same fold, disordered ligands, new functions
BACKGROUND: Signal fidelity depends on protein–protein interaction–‘hubs’ integrating cues from large interactomes. Recently, and based on a common secondary structure motif, the αα-hubs were defined, which are small α-helical domains of large, modular proteins binding intrinsically disordered trans...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788954/ https://www.ncbi.nlm.nih.gov/pubmed/33407551 http://dx.doi.org/10.1186/s12964-020-00686-8 |