Cargando…

Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma

BACKGROUND: The development of novel and effective drugs for targeted human hepatocellular carcinoma still remains a great challenge. The alkaloid nitidine chloride (NC), a component of a traditional Chinese medicine, has been shown to have anticancer properties, but doses at therapeutic levels have...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Danni, Liu, Shaogang, Zhu, Jiahao, Shen, Liqun, Zhang, Qi ying, Zhu, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789002/ https://www.ncbi.nlm.nih.gov/pubmed/33407916 http://dx.doi.org/10.1186/s40360-020-00461-y

Ejemplares similares

A novel nitidine chloride nanoparticle overcomes the stemness of CD133(+)EPCAM(+) Huh7 hepatocellular carcinoma cells for liver cancer therapy
por: Li, Danni, et al.
Publicado: (2022)

Insights into an NEk2 inhibitory profile of nitidine chloride by molecular docking and biological evaluation
por: Li, Danni, et al.
Publicado: (2022)

Antitumor functions and mechanisms of nitidine chloride in human cancers
por: Cui, Yue, et al.
Publicado: (2020)

Nitidine Chloride Inhibits SIN1 Expression in Osteosarcoma Cells
por: Xu, Hui, et al.
Publicado: (2019)

The expression characteristics and clinical significance of ACP6, a potential target of nitidine chloride, in hepatocellular carcinoma
por: Gao, Li, et al.
Publicado: (2022)

Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway
por: ZHAI, HUIYUAN, et al.
Publicado: (2016)

Nitidine chloride suppresses NEDD4 expression in lung cancer cells
por: Zhang, Jing, et al.
Publicado: (2020)

Nitidine Chloride Triggers Autophagy and Apoptosis of Ovarian Cancer Cells through Akt/mTOR Signaling Pathway
por: Lian, Chaoqun, et al.
Publicado: (2023)

TPGS2000-DOX Prodrug Micelles for Improving Breast Cancer Therapy
por: Tang, Lan, et al.
Publicado: (2021)

High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma
por: Xiong, Dan-dan, et al.
Publicado: (2019)

Enhanced Tumor Delivery of Gemcitabine via PEG-DSPE/TPGS Mixed Micelles
por: Wang, Yingzhe, et al.
Publicado: (2014)

Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways
por: Lin, Jiumao, et al.
Publicado: (2014)

Nitidine Chloride Alleviates Inflammation and Cellular Senescence in Murine Osteoarthritis Through Scavenging ROS
por: Lin, Changjian, et al.
Publicado: (2022)

TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems
por: Farooq, Muhammad Asim, et al.
Publicado: (2022)

Novel Agent Nitidine Chloride Induces Erythroid Differentiation and Apoptosis in CML Cells through c-Myc-miRNAs Axis
por: Liu, Na, et al.
Publicado: (2015)

TPGS/Phospholipids Mixed Micelles for Delivery of Icariside II to Multidrug-Resistant Breast Cancer
por: Song, Jie, et al.
Publicado: (2015)

Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy
por: Li, Weiguang, et al.
Publicado: (2019)

Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer
por: Saxena, Vipin, et al.
Publicado: (2012)

Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel
por: Ahmed, Tarek A, et al.
Publicado: (2019)

Nitidine chloride possesses anticancer property in lung cancer cells through activating Hippo signaling pathway
por: Zhang, Jing, et al.
Publicado: (2020)

Nitidine chloride induces cardiac hypertrophy in mice by targeting autophagy-related 4B cysteine peptidase
por: Hong, Yang, et al.
Publicado: (2022)

Nitidine chloride acts as an apoptosis inducer in human oral cancer cells and a nude mouse xenograft model via inhibition of STAT3
por: Kim, Lee-Han, et al.
Publicado: (2017)

Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation
por: Liu, Qian, et al.
Publicado: (2016)

DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride
por: Liu, Li-Min, et al.
Publicado: (2018)

Gene profiling of HepG2 cells following nitidine chloride treatment: An investigation with microarray and Connectivity Mapping
por: Liu, Li-Min, et al.
Publicado: (2019)

mPEG-PLA/TPGS mixed micelles via intranasal administration improved the bioavailability of lamotrigine in the hippocampus
por: Yu, Anan, et al.
Publicado: (2017)

Accurate delivery of pristimerin and paclitaxel by folic acid-linked nano-micelles for enhancing chemosensitivity in cancer therapy
por: Chen, Chao, et al.
Publicado: (2022)

Orally Administered Halofuginone-Loaded TPGS Polymeric Micelles Against Triple-Negative Breast Cancer: Enhanced Absorption and Efficacy with Reduced Toxicity and Metastasis
por: Zuo, Runan, et al.
Publicado: (2022)

Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles
por: Vuddanda, Parameswara Rao, et al.
Publicado: (2014)

Apigenin Sensitizes Huh-7 Human Hepatocellular Carcinoma Cells to TRAIL-induced Apoptosis
por: Kim, Eun Young, et al.
Publicado: (2012)

A new insight into the apoptotic effect of nitidine chloride targeting Checkpoint kinase 2 in human cervical cancer in vitro
por: Kwon, Hye-Jeong, et al.
Publicado: (2019)

Encapsulating Halofuginone Hydrobromide in TPGS Polymeric Micelles Enhances Efficacy Against Triple-Negative Breast Cancer Cells
por: Zuo, Runan, et al.
Publicado: (2021)

Improvement of Imiquimod Solubilization and Skin Retention via TPGS Micelles: Exploiting the Co-Solubilizing Effect of Oleic Acid
por: Ghezzi, Martina, et al.
Publicado: (2021)

Investigating the Potential of Transdermal Delivery of Avanafil Using Vitamin E-TPGS Based Mixed Micelles Loaded Films
por: Alamoudi, Abdullah A., et al.
Publicado: (2021)

TPGS-1000 exhibits potent anticancer activity for hepatocellular carcinoma in vitro and in vivo
por: Chen, Yidan, et al.
Publicado: (2020)

Nitidine chloride inhibits the appearance of cancer stem-like properties and regulates potential the mitochondrial membrane alterations of colon cancer cells
por: Gong, Hongyan, et al.
Publicado: (2020)

Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition
por: Chen, Zihang, et al.
Publicado: (2020)

Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer
por: Yu, Fei, et al.
Publicado: (2022)

Biodegradable mixed MPEG-SS-2SA/TPGS micelles for triggered intracellular release of paclitaxel and reversing multidrug resistance
por: Dong, Kai, et al.
Publicado: (2016)

Targeted delivery of ginsenoside compound K using TPGS/PEG-PCL mixed micelles for effective treatment of lung cancer
por: Yang, Lei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4l9dkpqbh44jlr1mlep87asskb