A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels

A novel missense mutation in the CACNA1A gene that encodes the pore forming α(1) subunit of the Ca(V)2.1 voltage-gated calcium channel was identified in a patient with trigeminal neuralgia. This mutation leads to a substitution of proline 2455 by histidine (P2455H) in the distal C-terminus region of...

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Detalles Bibliográficos
Autores principales: Gambeta, Eder, Gandini, Maria A., Souza, Ivana A., Ferron, Laurent, Zamponi, Gerald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789175/
https://www.ncbi.nlm.nih.gov/pubmed/33413531
http://dx.doi.org/10.1186/s13041-020-00725-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789175/
https://www.ncbi.nlm.nih.gov/pubmed/33413531
http://dx.doi.org/10.1186/s13041-020-00725-y

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