Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis

BACKGROUND: Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fibrosis. METHOD: Lrat:Cas9-ERT2:sgTif1γ mice were treated Tam...

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Detalles Bibliográficos
Autores principales: Hwang, Injoo, Lee, Eun Ju, Park, Hyomin, Moon, Dodam, Kim, Hyo-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789180/
https://www.ncbi.nlm.nih.gov/pubmed/33407858
http://dx.doi.org/10.1186/s13578-020-00509-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789180/
https://www.ncbi.nlm.nih.gov/pubmed/33407858
http://dx.doi.org/10.1186/s13578-020-00509-w

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