Overexpression of P-glycoprotein, MRP2, and CYP3A4 impairs intestinal absorption of octreotide in rats with portal hypertension

BACKGROUND: Portal hypertension (PH) is the main cause of complications and death in liver cirrhosis. The effect of oral administration of octreotide (OCT), a drug that reduces PH by the constriction of mesenteric arteries, is limited by a remarkable intestinal first-pass elimination. METHODS: The b...

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Detalles Bibliográficos
Autores principales: Sun, Xiaoyu, Tang, Shunxiong, Hou, Binbin, Duan, Zhijun, Liu, Zhen, Li, Yang, He, Shoucheng, Wang, Qiuming, Chang, Qingyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789354/
https://www.ncbi.nlm.nih.gov/pubmed/33407159
http://dx.doi.org/10.1186/s12876-020-01532-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789354/
https://www.ncbi.nlm.nih.gov/pubmed/33407159
http://dx.doi.org/10.1186/s12876-020-01532-4

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