Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier

BACKGROUND: Identifying essential genes in genome-wide loss-of-function screens is a critical step in functional genomics and cancer target finding. We previously described the Bayesian Analysis of Gene Essentiality (BAGEL) algorithm for accurate classification of gene essentiality from short hairpi...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Eiru, Hart, Traver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789424/
https://www.ncbi.nlm.nih.gov/pubmed/33407829
http://dx.doi.org/10.1186/s13073-020-00809-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789424/
https://www.ncbi.nlm.nih.gov/pubmed/33407829
http://dx.doi.org/10.1186/s13073-020-00809-3

Ejemplares similares