Anti-CD40 antibody KPL-404 inhibits T cell-mediated activation of B cells from healthy donors and autoimmune patients

BACKGROUND: CD40-CD40L is a key co-stimulatory pathway for B cell activation. As such, its blockade can inhibit pathogenic B cell responses in autoimmune diseases, such as Sjogren’s syndrome (SjS) and systemic lupus erythematosus (SLE). In this study, we examined the in vitro effects of KPL-404, a h...

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Detalles Bibliográficos
Autores principales: Marken, John, Muralidharan, Sujatha, Giltiay, Natalia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789801/
https://www.ncbi.nlm.nih.gov/pubmed/33407802
http://dx.doi.org/10.1186/s13075-020-02372-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789801/
https://www.ncbi.nlm.nih.gov/pubmed/33407802
http://dx.doi.org/10.1186/s13075-020-02372-z

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