Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia

6-Mercaptopurine (6-MP) is a thiopurine drug widely used in childhood acute lymphoblastic leukemia (ALL) therapy. Genes such as TPMT and NUDT15 have an outstanding role in 6-MP metabolism. Mutations in both genes explain a significant portion of hematological toxicities suffered by ALL Uruguayan ped...

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Detalles Bibliográficos
Autores principales: Burgueño-Rodríguez, Gabriela, Méndez, Yessika, Olano, Natalia, Dabezies, Agustín, Bertoni, Bernardo, Souto, Jorge, Castillo, Luis, da Luz, Julio, Soler, Ana María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789872/
https://www.ncbi.nlm.nih.gov/pubmed/33424606
http://dx.doi.org/10.3389/fphar.2020.594262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789872/
https://www.ncbi.nlm.nih.gov/pubmed/33424606
http://dx.doi.org/10.3389/fphar.2020.594262

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