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Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia

6-Mercaptopurine (6-MP) is a thiopurine drug widely used in childhood acute lymphoblastic leukemia (ALL) therapy. Genes such as TPMT and NUDT15 have an outstanding role in 6-MP metabolism. Mutations in both genes explain a significant portion of hematological toxicities suffered by ALL Uruguayan ped...

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Detalles Bibliográficos
Autores principales:	Burgueño-Rodríguez, Gabriela, Méndez, Yessika, Olano, Natalia, Dabezies, Agustín, Bertoni, Bernardo, Souto, Jorge, Castillo, Luis, da Luz, Julio, Soler, Ana María
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789872/ https://www.ncbi.nlm.nih.gov/pubmed/33424606 http://dx.doi.org/10.3389/fphar.2020.594262

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