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Syncytium cell growth increases Kir2.1 contribution in human iPSC-cardiomyocytes

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable cardiotoxicity testing and personalized medicine. However, their maturity is of concern, including relatively depolarized resting membrane potential and more spontaneous activity compared with adult cardiomyocytes, implica...

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Detalles Bibliográficos
Autores principales: Li, Weizhen, Han, Julie L., Entcheva, Emilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789971/
https://www.ncbi.nlm.nih.gov/pubmed/32986966
http://dx.doi.org/10.1152/ajpheart.00148.2020