Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response

The integrated stress response manifests with the phosphorylation of eukaryotic initiation factor 2α (eIF2α) on serine residue 51 and plays a major role in the adaptation of cells to endoplasmic reticulum stress in the initiation of autophagy and in the ignition of immune responses. Here, we report...

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Detalles Bibliográficos
Autores principales: Tian, Ai-Ling, Wu, Qi, Liu, Peng, Zhao, Liwei, Martins, Isabelle, Kepp, Oliver, Leduc, Marion, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790317/
https://www.ncbi.nlm.nih.gov/pubmed/33414432
http://dx.doi.org/10.1038/s41419-020-03324-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790317/
https://www.ncbi.nlm.nih.gov/pubmed/33414432
http://dx.doi.org/10.1038/s41419-020-03324-w

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