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Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response
The integrated stress response manifests with the phosphorylation of eukaryotic initiation factor 2α (eIF2α) on serine residue 51 and plays a major role in the adaptation of cells to endoplasmic reticulum stress in the initiation of autophagy and in the ignition of immune responses. Here, we report...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790317/ https://www.ncbi.nlm.nih.gov/pubmed/33414432 http://dx.doi.org/10.1038/s41419-020-03324-w |