TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction

The telomeric shelterin protein telomeric repeat-binding factor 2 (TRF2) recruits origin recognition complex (ORC) proteins, the foundational building blocks of DNA replication origins, to telomeres. We seek to determine whether TRF2-recruited ORC proteins give rise to functional origins in telomere...

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Detalles Bibliográficos
Autores principales: Drosopoulos, William C., Deng, Zhong, Twayana, Shyam, Kosiyatrakul, Settapong T., Vladimirova, Olga, Lieberman, Paul M., Schildkraut, Carl L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790361/
https://www.ncbi.nlm.nih.gov/pubmed/33176153
http://dx.doi.org/10.1016/j.celrep.2020.108379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790361/
https://www.ncbi.nlm.nih.gov/pubmed/33176153
http://dx.doi.org/10.1016/j.celrep.2020.108379

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