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TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction
The telomeric shelterin protein telomeric repeat-binding factor 2 (TRF2) recruits origin recognition complex (ORC) proteins, the foundational building blocks of DNA replication origins, to telomeres. We seek to determine whether TRF2-recruited ORC proteins give rise to functional origins in telomere...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790361/ https://www.ncbi.nlm.nih.gov/pubmed/33176153 http://dx.doi.org/10.1016/j.celrep.2020.108379 |