Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds

Children with Down syndrome have an approximately 10-fold increased risk of developing acute lymphoblastic leukemia and this risk is influenced by inherited genetic variation. Genome-wide association studies have identified IKZF1 as a strong acute lymphoblastic leukemia susceptibility locus in child...

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Detalles Bibliográficos
Autores principales: Gant, Vincent U., Junco, Jacob J., Terrell, Maci, Rashid, Raushan, Rabin, Karen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790404/
https://www.ncbi.nlm.nih.gov/pubmed/33411777
http://dx.doi.org/10.1371/journal.pone.0244863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790404/
https://www.ncbi.nlm.nih.gov/pubmed/33411777
http://dx.doi.org/10.1371/journal.pone.0244863

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