Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration

Rab-GTPases and associated effectors mediate cargo transport through the endomembrane system of eukaryotic cells, regulating key processes such as membrane turnover, signal transduction, protein recycling and degradation. Using developmental transcriptome data, we identified Rabgef1 (encoding the pr...

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Detalles Bibliográficos
Autores principales: Hargrove-Grimes, Passley, Mondal, Anupam K., Gumerson, Jessica, Nellissery, Jacob, Aponte, Angel M., Gieser, Linn, Qian, Haohua, Fariss, Robert N., Bonifacino, Juan S., Li, Tiansen, Swaroop, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790415/
https://www.ncbi.nlm.nih.gov/pubmed/33362196
http://dx.doi.org/10.1371/journal.pgen.1009259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790415/
https://www.ncbi.nlm.nih.gov/pubmed/33362196
http://dx.doi.org/10.1371/journal.pgen.1009259

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