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Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration
Rab-GTPases and associated effectors mediate cargo transport through the endomembrane system of eukaryotic cells, regulating key processes such as membrane turnover, signal transduction, protein recycling and degradation. Using developmental transcriptome data, we identified Rabgef1 (encoding the pr...
Autores principales: | Hargrove-Grimes, Passley, Mondal, Anupam K., Gumerson, Jessica, Nellissery, Jacob, Aponte, Angel M., Gieser, Linn, Qian, Haohua, Fariss, Robert N., Bonifacino, Juan S., Li, Tiansen, Swaroop, Anand |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790415/ https://www.ncbi.nlm.nih.gov/pubmed/33362196 http://dx.doi.org/10.1371/journal.pgen.1009259 |
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