Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers

Genes involved in 3′-splice site recognition during mRNA splicing constitute an emerging class of oncogenes. SF3B1 is the most frequently mutated splicing factor in cancer, and SF3B1 mutants corrupt branchpoint recognition leading to usage of cryptic 3′-splice sites and subsequent aberrant junctions...

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Detalles Bibliográficos
Autores principales: Alsafadi, Samar, Dayot, Stephane, Tarin, Malcy, Houy, Alexandre, Bellanger, Dorine, Cornella, Michele, Wassef, Michel, Waterfall, Joshua J., Lehnert, Erik, Roman-Roman, Sergio, Stern, Marc-Henri, Popova, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790757/
https://www.ncbi.nlm.nih.gov/pubmed/33057152
http://dx.doi.org/10.1038/s41388-020-01507-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790757/
https://www.ncbi.nlm.nih.gov/pubmed/33057152
http://dx.doi.org/10.1038/s41388-020-01507-5

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