Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation

The IκB kinase complex, consisting of IKK1, IKK2 and the regulatory subunit NEMO, is required for NF-κB signalling following the activation of several cell surface receptors, such as members of the Tumour Necrosis Factor Receptor superfamily and the Interleukin-1 Receptor. This is critical for haema...

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Detalles Bibliográficos
Autores principales: Fischer, Karla C., Daunt, Carmel P., Tremblay, Cédric S., Dias, Sheila, Vince, James E., Jabbour, Anissa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791118/
https://www.ncbi.nlm.nih.gov/pubmed/33414459
http://dx.doi.org/10.1038/s41419-020-03298-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791118/
https://www.ncbi.nlm.nih.gov/pubmed/33414459
http://dx.doi.org/10.1038/s41419-020-03298-9

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