Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway

BACKGROUND: Doxorubicin is an anthracycline antibiotic, which is effective for treating various malignancies such as leukemias and lymphomas. However, its serious cumulative dose-dependent cardiotoxicity limits its clinical application. Previous studies have shown that doxorubicin-associated cardiot...

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Detalles Bibliográficos
Autores principales: Wang, Jiawei, Fan, Yixin, Cai, Xiaomin, Gao, Zhenzhen, Yu, Zhengyi, Wei, Bin, Tang, Yulin, Hu, Liang, Liu, Wen-Tao, Gu, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791217/
https://www.ncbi.nlm.nih.gov/pubmed/33437769
http://dx.doi.org/10.21037/atm-20-3105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791217/
https://www.ncbi.nlm.nih.gov/pubmed/33437769
http://dx.doi.org/10.21037/atm-20-3105

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