Delaying the final cut: A close encounter of checkpoint kinases at the midbody

How chromatin bridges are relayed to the chromosomal passenger complex (CPC) during mammalian cell division is unknown. In this issue, Petsalaki and Zachos (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202008029) show that the DNA damage checkpoint kinases ATM and Chk2 signal to the CPC to associ...

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Detalles Bibliográficos
Autores principales: Hadders, Michael A., Lens, Susanne M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791345/
https://www.ncbi.nlm.nih.gov/pubmed/33404606
http://dx.doi.org/10.1083/jcb.202012130
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author Hadders, Michael A.
Lens, Susanne M.A.
author_facet Hadders, Michael A.
Lens, Susanne M.A.
author_sort Hadders, Michael A.
collection PubMed
description How chromatin bridges are relayed to the chromosomal passenger complex (CPC) during mammalian cell division is unknown. In this issue, Petsalaki and Zachos (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202008029) show that the DNA damage checkpoint kinases ATM and Chk2 signal to the CPC to associate with a pool of cytoskeletal regulators, MKLP2–Cep55, in the midbody center and to delay abscission.
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spelling pubmed-77913452021-08-01 Delaying the final cut: A close encounter of checkpoint kinases at the midbody Hadders, Michael A. Lens, Susanne M.A. J Cell Biol Spotlight How chromatin bridges are relayed to the chromosomal passenger complex (CPC) during mammalian cell division is unknown. In this issue, Petsalaki and Zachos (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202008029) show that the DNA damage checkpoint kinases ATM and Chk2 signal to the CPC to associate with a pool of cytoskeletal regulators, MKLP2–Cep55, in the midbody center and to delay abscission. Rockefeller University Press 2021-01-06 /pmc/articles/PMC7791345/ /pubmed/33404606 http://dx.doi.org/10.1083/jcb.202012130 Text en © 2020 Hadders and Lens http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Hadders, Michael A.
Lens, Susanne M.A.
Delaying the final cut: A close encounter of checkpoint kinases at the midbody
title Delaying the final cut: A close encounter of checkpoint kinases at the midbody
title_full Delaying the final cut: A close encounter of checkpoint kinases at the midbody
title_fullStr Delaying the final cut: A close encounter of checkpoint kinases at the midbody
title_full_unstemmed Delaying the final cut: A close encounter of checkpoint kinases at the midbody
title_short Delaying the final cut: A close encounter of checkpoint kinases at the midbody
title_sort delaying the final cut: a close encounter of checkpoint kinases at the midbody
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791345/
https://www.ncbi.nlm.nih.gov/pubmed/33404606
http://dx.doi.org/10.1083/jcb.202012130
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