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Quantifying the effects of biopsy fixation and staining panel design on automatic instance segmentation of immune cells in human lupus nephritis

Significance: Lupus nephritis (LuN) is a chronic inflammatory kidney disease. The cellular mechanisms by which LuN progresses to kidney failure are poorly characterized. Automated instance segmentation of immune cells in immunofluorescence images of LuN can probe these cellular interactions. Aim: Ou...

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Detalles Bibliográficos
Autores principales: Durkee, Madeleine S., Abraham, Rebecca, Ai, Junting, Veselits, Margaret, Clark, Marcus R., Giger, Maryellen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791891/
https://www.ncbi.nlm.nih.gov/pubmed/33420765
http://dx.doi.org/10.1117/1.JBO.26.2.022910