14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model

Alpha-synuclein (αsyn) is the key component of proteinaceous aggregates termed Lewy Bodies that pathologically define a group of disorders known as synucleinopathies, including Parkinson’s Disease (PD) and Dementia with Lewy Bodies. αSyn is hypothesized to misfold and spread throughout the brain in...

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Detalles Bibliográficos
Autores principales: Underwood, Rachel, Gannon, Mary, Pathak, Aneesh, Kapa, Navya, Chandra, Sidhanth, Klop, Alyssa, Yacoubian, Talene A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792107/
https://www.ncbi.nlm.nih.gov/pubmed/33413679
http://dx.doi.org/10.1186/s40478-020-01110-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792107/
https://www.ncbi.nlm.nih.gov/pubmed/33413679
http://dx.doi.org/10.1186/s40478-020-01110-5

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