Infrapatellar fat pad-derived mesenchymal stem cell-based spheroids enhance their therapeutic efficacy to reverse synovitis and fat pad fibrosis

BACKGROUND: To investigate the in vitro and in vivo anti-inflammatory/anti-fibrotic capacity of IFP-MSC manufactured as 3D spheroids. Our hypothesis is that IFP-MSC do not require prior cell priming to acquire a robust immunomodulatory phenotype in vitro in order to efficiently reverse synovitis and...

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Detalles Bibliográficos
Autores principales: Kouroupis, Dimitrios, Willman, Melissa A., Best, Thomas M., Kaplan, Lee D., Correa, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792122/
https://www.ncbi.nlm.nih.gov/pubmed/33413649
http://dx.doi.org/10.1186/s13287-020-02107-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792122/
https://www.ncbi.nlm.nih.gov/pubmed/33413649
http://dx.doi.org/10.1186/s13287-020-02107-6

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