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HIV Protease Inhibitor Ritonavir Impairs Endothelial Function Via Reduction in Adipose Mass and Endothelial Leptin Receptor‐Dependent Increases in NADPH Oxidase 1 (Nox1), C‐C Chemokine Receptor Type 5 (CCR5), and Inflammation

BACKGROUND: Cardiovascular disease is currently the leading cause of death in patients with human immunodeficiency virus on combination antiretroviral therapy. Although the use of the protease inhibitor ritonavir has been associated with increased prevalence of cardiovascular disease, the underlying...

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Detalles Bibliográficos
Autores principales: Bruder‐Nascimento, Thiago, Kress, Taylor C., Kennard, Simone, Belin de Chantemèle, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792423/
https://www.ncbi.nlm.nih.gov/pubmed/33003981
http://dx.doi.org/10.1161/JAHA.120.018074