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The neuroprotective effects of pregabalin after cerebral ischemia by occlusion of the middle cerebral artery in rats
Activation of presynaptic voltage-gated calcium channels and glutamate release serves a central role in neuronal necrosis after cerebral ischemia. Pregabalin binds to the α2-δ subunit of voltage-gated calcium channels and results in reduced glutamate release. The aim of the current study was to eval...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792490/ https://www.ncbi.nlm.nih.gov/pubmed/33456532 http://dx.doi.org/10.3892/etm.2020.9596 |