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Pembrolizumab Induces an Unexpected Conformational Change in the CC′-loop of PD-1
SIMPLE SUMMARY: Cancer cells are normally destructed by killer T-cells. However, T-cells expose the PD-1 receptor on their surface, acting as a checkpoint: If it is activated through a special molecule, PD-L1, the T-cell kills itself, ending the attack. Cells often need to present PD-L1 to prevent T...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792774/ https://www.ncbi.nlm.nih.gov/pubmed/33375020 http://dx.doi.org/10.3390/cancers13010005 |