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Development of Second Generation Activity-Based Chemical Probes for Sirtuins

NAD(+) (nicotinamide adenine dinucleotide)-dependent protein deacylases, namely, the sirtuins, are important cell adaptor proteins that alter cell physiology in response to low calorie conditions. They are thought to mediate the beneficial effects of calorie restriction to extend longevity and impro...

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Detalles Bibliográficos
Autores principales: Curry, Alyson M., Barton, Elizabeth, Kang, Wenjia, Mongeluzi, Daniel V., Cen, Yana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792806/
https://www.ncbi.nlm.nih.gov/pubmed/33375102
http://dx.doi.org/10.3390/molecules26010011