Pharmacological Characterization of µ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Activation

In recent years, G protein vs. β-arrestin biased agonism at opioid receptors has been proposed as an opportunity to produce antinociception with reduced adverse effects. However, at present this approach is highly debated, a reason why more information about biased ligands is required. While the pra...

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Detalles Bibliográficos
Autores principales: Piekielna-Ciesielska, Justyna, Artali, Roberto, Azzam, Ammar A. H., Lambert, David G., Kluczyk, Alicja, Gentilucci, Luca, Janecka, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792944/
https://www.ncbi.nlm.nih.gov/pubmed/33375124
http://dx.doi.org/10.3390/molecules26010013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792944/
https://www.ncbi.nlm.nih.gov/pubmed/33375124
http://dx.doi.org/10.3390/molecules26010013

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