Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells

SIMPLE SUMMARY: High levels of global genome methylation in HPV-associated head and neck cancer prompted us to explore demethylation as a potential treatment by determining mechanisms of its toxicity in HPV-positive head and neck cancer cells. Previously, we reported that demethylating drug 5-azaC s...

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Detalles Bibliográficos
Autores principales: Hajek, Michael, Biktasova, Asel, Sewell, Andrew, Gary, Cyril, Cantalupo, Paul, Anderson, Karen S., Yarbrough, Wendell G., Issaeva, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793113/
https://www.ncbi.nlm.nih.gov/pubmed/33374558
http://dx.doi.org/10.3390/cancers13010021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793113/
https://www.ncbi.nlm.nih.gov/pubmed/33374558
http://dx.doi.org/10.3390/cancers13010021

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