Mitochondrial Ca(2+) Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing

Phagocytes reallocate metabolic resources to kill engulfed pathogens, but the intracellular signals that rapidly switch the immunometabolic program necessary to fuel microbial killing are not understood. We report that macrophages use a fast two-step Ca(2+) relay to meet the bioenergetic demands of...

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Detalles Bibliográficos
Autores principales: Seegren, Philip V., Downs, Taylor K., Stremska, Marta E., Harper, Logan R., Cao, Ruofan, Olson, Rachel J., Upchurch, Clint M., Doyle, Catherine A., Kennedy, Joel, Stipes, Eric L., Leitinger, Norbert, Periasamy, Ammasi, Desai, Bimal N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793167/
https://www.ncbi.nlm.nih.gov/pubmed/33238121
http://dx.doi.org/10.1016/j.celrep.2020.108411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793167/
https://www.ncbi.nlm.nih.gov/pubmed/33238121
http://dx.doi.org/10.1016/j.celrep.2020.108411

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