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Mitochondrial Ca(2+) Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing
Phagocytes reallocate metabolic resources to kill engulfed pathogens, but the intracellular signals that rapidly switch the immunometabolic program necessary to fuel microbial killing are not understood. We report that macrophages use a fast two-step Ca(2+) relay to meet the bioenergetic demands of...
Autores principales: | Seegren, Philip V., Downs, Taylor K., Stremska, Marta E., Harper, Logan R., Cao, Ruofan, Olson, Rachel J., Upchurch, Clint M., Doyle, Catherine A., Kennedy, Joel, Stipes, Eric L., Leitinger, Norbert, Periasamy, Ammasi, Desai, Bimal N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793167/ https://www.ncbi.nlm.nih.gov/pubmed/33238121 http://dx.doi.org/10.1016/j.celrep.2020.108411 |
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