High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη Induction

SIMPLE SUMMARY: Cervical cancers (CaCx) are caused by the expression of human papillomavirus oncogenes (HPV E6 and E7). Here, in vitro assays, computational approaches and immunohistochemical analysis of cervical biopsies show that HPV oncogenes impair translesion synthesis (TLS). This limits the pa...

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Detalles Bibliográficos
Autores principales: Wendel, Sebastian O., Snow, Jazmine A., Bastian, Tyler, Brown, Laura, Hernandez, Candy, Burghardt, Emily, Kahn, Andrew, Murthy, Vaibhav, Neill, Daniel, Smith, Zachary C., Ault, Kevin, Tawfik, Ossama, Wu, Cen, Wallace, Nicholas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793514/
https://www.ncbi.nlm.nih.gov/pubmed/33374731
http://dx.doi.org/10.3390/cancers13010028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793514/
https://www.ncbi.nlm.nih.gov/pubmed/33374731
http://dx.doi.org/10.3390/cancers13010028

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