Cargando…

High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη Induction

SIMPLE SUMMARY: Cervical cancers (CaCx) are caused by the expression of human papillomavirus oncogenes (HPV E6 and E7). Here, in vitro assays, computational approaches and immunohistochemical analysis of cervical biopsies show that HPV oncogenes impair translesion synthesis (TLS). This limits the pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wendel, Sebastian O., Snow, Jazmine A., Bastian, Tyler, Brown, Laura, Hernandez, Candy, Burghardt, Emily, Kahn, Andrew, Murthy, Vaibhav, Neill, Daniel, Smith, Zachary C., Ault, Kevin, Tawfik, Ossama, Wu, Cen, Wallace, Nicholas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793514/ https://www.ncbi.nlm.nih.gov/pubmed/33374731 http://dx.doi.org/10.3390/cancers13010028

Ejemplares similares

HPV 16 E7 alters translesion synthesis signaling
por: Wendel, Sebastian O., et al.
Publicado: (2022)

Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis
por: Peddu, Chandana, et al.
Publicado: (2018)

Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
por: Ma, Xiaolu, et al.
Publicado: (2017)

Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts
por: Schmutz, Valérie, et al.
Publicado: (2010)

β-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV Damage
por: Snow, Jazmine A., et al.
Publicado: (2019)

Translesion activity of PrimPol on DNA with cisplatin and DNA–protein cross-links
por: Boldinova, Elizaveta O., et al.
Publicado: (2021)

Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions
por: Hirota, Kouji, et al.
Publicado: (2010)

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres
por: Garcia-Exposito, Laura, et al.
Publicado: (2016)

Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes
por: Ghazi, Madeeha, et al.
Publicado: (2023)

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity
por: Mentegari, Elisa, et al.
Publicado: (2017)

Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA
por: Lau, Wilson C. Y., et al.
Publicado: (2015)

The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility
por: Powers, Kyle T, et al.
Publicado: (2018)

Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function
por: Gali, Vamsi K., et al.
Publicado: (2017)

The ubiquitin-binding domain of DNA polymerase η directly binds to DNA clamp PCNA and regulates translesion DNA synthesis
por: Manohar, Kodavati, et al.
Publicado: (2021)

Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle
por: Bertoletti, Federica, et al.
Publicado: (2017)

Deficiency of Polη in Saccharomyces cerevisiae reveals the impact of transcription on damage-induced cohesion
por: Wu, Pei-Shang, et al.
Publicado: (2021)

Manganese Is a Strong Specific Activator of the RNA Synthetic Activity of Human Polη
por: Balint, Eva, et al.
Publicado: (2021)

Expression of DNA Translesion Synthesis Polymerase η in Head and Neck Squamous Cell Cancer Predicts Resistance to Gemcitabine and Cisplatin-Based Chemotherapy
por: Zhou, Wendi, et al.
Publicado: (2013)

Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N(2)-ethenodeoxyguanosine by human DNA translesion polymerase η
por: Ghodke, Pratibha P., et al.
Publicado: (2021)

FF(483–484) motif of human Polη mediates its interaction with the POLD2 subunit of Polδ and contributes to DNA damage tolerance
por: Baldeck, Nadège, et al.
Publicado: (2015)

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis
por: Bergoglio, Valérie, et al.
Publicado: (2013)

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ
por: Tellier-Lebegue, Carine, et al.
Publicado: (2017)

DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη
por: Qin, Zhoushuai, et al.
Publicado: (2013)

Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity
por: Zhang, Qi, et al.
Publicado: (2023)

Translesion DNA Polymerases and Cancer
por: Makridakis, Nick M., et al.
Publicado: (2012)

Post-translesion synthesis repair
por: Jansen, Jacob G., et al.
Publicado: (2015)

Correction: The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ
por: Tellier-Lebegue, Carine, et al.
Publicado: (2018)

PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching
por: Tsuda, Masataka, et al.
Publicado: (2019)

Importance of Polη for Damage-Induced Cohesion Reveals Differential Regulation of Cohesion Establishment at the Break Site and Genome-Wide
por: Enervald, Elin, et al.
Publicado: (2013)

Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots
por: Krantsevich, Artem, et al.
Publicado: (2021)

Photo-activatable Ub-PCNA probes reveal new structural features of the Saccharomyces cerevisiae Polη/PCNA complex
por: Shen, Siqi, et al.
Publicado: (2021)

Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells
por: Bi, Tonghui, et al.
Publicado: (2021)

Polη, Polζ and Rev1 together are required for G to T transversion mutations induced by the (+)- and (−)-trans-anti-BPDE-N(2)-dG DNA adducts in yeast cells
por: Zhao, Bo, et al.
Publicado: (2006)

Polη, Polζ and Rev1 together are required for G to T transversion mutations induced by the (+)- and (−)-trans-anti-BPDE-N(2)-dG DNA adducts in yeast cells
por: Zhao, Bo, et al.
Publicado: (2006)

c-Jun N-terminal kinase–mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks
por: Barkley, Laura R., et al.
Publicado: (2012)

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes
por: Tang, Catherine, et al.
Publicado: (2020)

Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1
por: Weaver, Tyler M., et al.
Publicado: (2022)

Multiple Strategies for Translesion Synthesis in Bacteria
por: Ippoliti, Paul J., et al.
Publicado: (2012)

Protein–Protein Interactions in Translesion Synthesis
por: Dash, Radha Charan, et al.
Publicado: (2021)

The role of hRev7, the accessory subunit of hPolζ, in translesion synthesis past DNA damage induced by benzo[a]pyrene diol epoxide (BPDE)
por: Neal, Jessica A, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_vrdhcn9t85709cth8j8eusjpkg