Urea-Peptide Hybrids as VEGF-A(165)/NRP-1 Complex Inhibitors with Improved Receptor Affinity and Biological Properties

Neuropilin-1 (NRP-1), the major co-receptor of vascular endothelial growth factor receptor-2 (VEGFR-2), may also independently act with VEGF-A(165) to stimulate tumour growth and metastasis. Therefore, there is great interest in compounds that can block VEGF-A165/NRP-1 interaction. Peptidomimetic ty...

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Detalles Bibliográficos
Autores principales: Puszko, Anna K., Sosnowski, Piotr, Rignault-Bricard, Rachel, Hermine, Olivier, Hopfgartner, Gérard, Pułka-Ziach, Karolina, Lepelletier, Yves, Misicka, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793531/
https://www.ncbi.nlm.nih.gov/pubmed/33374715
http://dx.doi.org/10.3390/ijms22010072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793531/
https://www.ncbi.nlm.nih.gov/pubmed/33374715
http://dx.doi.org/10.3390/ijms22010072

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