Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies

The chromatin-modifying histone deacetylases (HDACs) remove acetyl groups from acetyl-lysine residues in histone amino-terminal tails, thereby mediating transcriptional repression. Structural makeup and mechanisms by which multisubunit HDAC complexes recognize nucleosomes remain elusive. Our cryo–el...

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Detalles Bibliográficos
Autores principales: Lee, Jung-Hoon, Bollschweiler, Daniel, Schäfer, Tillman, Huber, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793584/
https://www.ncbi.nlm.nih.gov/pubmed/33523989
http://dx.doi.org/10.1126/sciadv.abd4413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793584/
https://www.ncbi.nlm.nih.gov/pubmed/33523989
http://dx.doi.org/10.1126/sciadv.abd4413

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