Cargando…

Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies

The chromatin-modifying histone deacetylases (HDACs) remove acetyl groups from acetyl-lysine residues in histone amino-terminal tails, thereby mediating transcriptional repression. Structural makeup and mechanisms by which multisubunit HDAC complexes recognize nucleosomes remain elusive. Our cryo–el...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Jung-Hoon, Bollschweiler, Daniel, Schäfer, Tillman, Huber, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793584/ https://www.ncbi.nlm.nih.gov/pubmed/33523989 http://dx.doi.org/10.1126/sciadv.abd4413

Ejemplares similares

Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex
por: Dong, Shuqi, et al.
Publicado: (2023)

Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone
por: Cho, Carol, et al.
Publicado: (2019)

Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast
por: Seo, Jinwon, et al.
Publicado: (2014)

Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins
por: Dai, Yan, et al.
Publicado: (2008)

Regulating the Regulators: The Role of Histone Deacetylase 1 (HDAC1) in Erythropoiesis
por: Kim, Min Young, et al.
Publicado: (2020)

Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis
por: Ghazy, Ehab, et al.
Publicado: (2022)

The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs
por: Vaca, Hugo Rolando, et al.
Publicado: (2021)

Structure-Based Inhibitor Discovery of Class I Histone Deacetylases (HDACs)
por: Luo, Yuxiang, et al.
Publicado: (2020)

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni
por: Marek, Martin, et al.
Publicado: (2013)

The Histone Deacetylase HDAC4 Regulates Long-Term Memory in Drosophila
por: Fitzsimons, Helen L., et al.
Publicado: (2013)

Diverse nucleosome Site-Selectivity among histone deacetylase complexes
por: Wang, Zhipeng A, et al.
Publicado: (2020)

Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo
por: Kelly, R. D. W., et al.
Publicado: (2018)

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
por: Wagner, Julia M., et al.
Publicado: (2010)

The histone deacetylase Hdac1 regulates inflammatory signalling in intestinal epithelial cells
por: Gonneaud, Alexis, et al.
Publicado: (2014)

Histone Deacetylase Inhibitors, Intrinsic and Extrinsic Apoptotic Pathways, and Epigenetic Alterations of Histone Deacetylases (HDACs) in Hepatocellular Carcinoma
por: Sanaei, Masumeh, et al.
Publicado: (2021)

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases
por: Moreno-Yruela, Carlos, et al.
Publicado: (2022)

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase
por: Jang, Seongmin, et al.
Publicado: (2019)

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition
por: Hai, Yang, et al.
Publicado: (2016)

Crystal Structure of Malaria Parasite Nucleosome Assembly Protein: DISTINCT MODES OF PROTEIN LOCALIZATION AND HISTONE RECOGNITION
por: Gill, Jasmita, et al.
Publicado: (2009)

Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer
por: Xu, Xiaoxin S, et al.
Publicado: (2011)

The Role of Dietary Histone Deacetylases (HDACs) Inhibitors in Health and Disease
por: Bassett, Shalome A., et al.
Publicado: (2014)

Histone Deacetylases (HDACs) Guided Novel Therapies for T-cell lymphomas
por: Zhang, Qing, et al.
Publicado: (2019)

Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review
por: Chen, Xiaona, et al.
Publicado: (2020)

Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase
por: Anderson, Cathy J., et al.
Publicado: (2019)

Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting
por: Itoh, Toshimasa, et al.
Publicado: (2015)

Histone deacetylase HDAC2 regulates microRNA‐125a expression in neuroblastoma
por: Liu, Denghui, et al.
Publicado: (2022)

Histone modifications regulate DNA replication coupled nucleosome assembly
por: Han, Junhong, et al.
Publicado: (2013)

CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2
por: Boucheron, Nicole, et al.
Publicado: (2014)

Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors
por: Galán, María, et al.
Publicado: (2016)

Structural Paradigms in the Recognition of the Nucleosome Core Particle by Histone Lysine Methyltransferases
por: Janna, Ashley, et al.
Publicado: (2020)

Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4
por: Park, Suk-Youl, et al.
Publicado: (2018)

Relationship Between Histone Deacetylase 3 (HDAC3) and Breast Cancer
por: Cui, Zhuhong, et al.
Publicado: (2018)

Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs
por: Wang, Yuren, et al.
Publicado: (2017)

Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome
por: Worden, Evan J, et al.
Publicado: (2020)

Structural basis of telomeric nucleosome recognition by shelterin factor TRF1
por: Hu, Hongmiao, et al.
Publicado: (2023)

Histone Chaperone-Mediated Nucleosome Assembly Process
por: Fan, Hsiu-Fang, et al.
Publicado: (2015)

Optimization of Resveratrol Used as a Scaffold to Design Histone Deacetylase (HDAC-1 and HDAC-2) Inhibitors
por: Urias, Beatriz Silva, et al.
Publicado: (2022)

The histone deacetylase HDAC1 positively regulates Notch signaling during Drosophila wing development
por: Wang, Zehua, et al.
Publicado: (2018)

The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications
por: Li, Yanjing, et al.
Publicado: (2022)

Balancing Histone Deacetylase (HDAC) Inhibition and Drug‐likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors
por: Schäker‐Hübner, Linda, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vbq7acdt4oqq6jt7569tptu6gg