The Role of Norrish Type-I Chemistry in Photoactive Drugs: An ab initio Study of a Cyclopropenone-Enediyne Drug Precursor

We present a contemporary mechanistic description of the light-driven conversion of cyclopropenone containing enediyne (CPE) precusors to ring-opened species amenable to further Bergman cyclization and formation of stable biradical species that have been proposed for use in light-induced cancer trea...

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Detalles Bibliográficos
Autores principales: Léger, Spencer J., Marchetti, Barbara, Ashfold, Michael N. R., Karsili, Tolga N. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793749/
https://www.ncbi.nlm.nih.gov/pubmed/33425854
http://dx.doi.org/10.3389/fchem.2020.596590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793749/
https://www.ncbi.nlm.nih.gov/pubmed/33425854
http://dx.doi.org/10.3389/fchem.2020.596590

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