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ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function
Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme for sphingolipid biosynthesis in cells. A decade ago, several genome wide association studies revealed single nucleotide polym...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793773/ https://www.ncbi.nlm.nih.gov/pubmed/33424845 http://dx.doi.org/10.3389/fimmu.2020.597945 |