Cargando…

ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function

Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme for sphingolipid biosynthesis in cells. A decade ago, several genome wide association studies revealed single nucleotide polym...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luthers, Christopher R., Dunn, Teresa M., Snow, Andrew L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793773/ https://www.ncbi.nlm.nih.gov/pubmed/33424845 http://dx.doi.org/10.3389/fimmu.2020.597945

Ejemplares similares

The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice
por: Clarke, Benjamin A, et al.
Publicado: (2019)

ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling
por: Bugajev, Viktor, et al.
Publicado: (2021)

CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism
por: Green, Christopher D., et al.
Publicado: (2021)

Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis
por: Xie, Tian, et al.
Publicado: (2023)

Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice
por: James, Briana N., et al.
Publicado: (2023)

Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways
por: Bugajev, Viktor, et al.
Publicado: (2021)

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway
por: Li, Jia, et al.
Publicado: (2021)

Rice ORMDL Controls Sphingolipid Homeostasis Affecting Fertility Resulting from Abnormal Pollen Development
por: Chueasiri, Chutharat, et al.
Publicado: (2014)

“Stick a Fork in Me; I’m Done”: Epithelial Cell Expression of ORMDL Sphingolipid Biosynthesis Regulator 3 Mediates Autophagic Cell Death
por: Curtiss, Miranda L., et al.
Publicado: (2022)

The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis
por: Zhao, Chun-Ni, et al.
Publicado: (2015)

SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins
por: Lone, Museer A., et al.
Publicado: (2022)

Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy
por: Sun, Yixiao, et al.
Publicado: (2022)

Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock
por: Chang, Matthew L., et al.
Publicado: (2019)

ORMDL3 is associated with airway remodeling in asthma via the ERK/MMP-9 pathway
por: Yu, Fei, et al.
Publicado: (2017)

Fighting the Common Cold: ORMDL3 in the Crosshairs?
por: Ito, Kazuhiro, et al.
Publicado: (2020)

ORMDL3‑mediated bronchial epithelial pyroptosis leads to lung inflammation in obese mice with asthma
por: Liu, Fan, et al.
Publicado: (2023)

Altered sphingolipid pathway in SARS-CoV-2 infected human lung tissue
por: Khan, Rabisa J., et al.
Publicado: (2023)

Association between peripheral blood mononuclear cell ORMDL3 expression and the asthma predictive index in preschool children
por: Li, Yaqin, et al.
Publicado: (2019)

ORMDL3 Promotes Angiogenesis in Chronic Asthma Through the ERK1/2/VEGF/MMP-9 Pathway
por: Ding, Zhen, et al.
Publicado: (2022)

Ormdl3 regulation of specific ceramides is dispensable for β-cell function and glucose homeostasis under obesogenic conditions
por: Hurley, Liam D, et al.
Publicado: (2023)

Sphingolipids and their enigmatic role in asthma
por: Sturgill, Jamie L.
Publicado: (2018)

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48
por: Ha, Sung Gil, et al.
Publicado: (2013)

All-Trans Retinoic Acid Modulates ORMDL3 Expression via Transcriptional Regulation
por: Zhuang, Li-Li, et al.
Publicado: (2013)

ORMDL3 regulates poly I:C induced inflammatory responses in airway epithelial cells
por: Laura, Gemma, et al.
Publicado: (2021)

Ormdl3 regulation of specific ceramides is dispensable for mouse β-cell function and glucose homeostasis under obesogenic conditions
por: Hurley, Liam D., et al.
Publicado: (2023)

Cholesterol Efflux Pathways Regulate Myelopoiesis: A Potential Link to Altered Macrophage Function in Atherosclerosis
por: Murphy, Andrew James, et al.
Publicado: (2014)

Fatty Acid Synthase Contributes to Restimulation-Induced Cell Death of Human CD4 T Cells
por: Voss, Kelsey, et al.
Publicado: (2019)

Sphingolipids, mycobacteria and host: Unraveling the tug of war
por: Mohammed, Shakeel Ahmed, et al.
Publicado: (2022)

ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility
por: Pham, Alexa K., et al.
Publicado: (2021)

Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease
por: Löser, Stephan, et al.
Publicado: (2017)

Sphingolipid biosynthesis in man and microbes
por: Harrison, Peter J., et al.
Publicado: (2018)

Sphingolipid metabolism in T cell responses after allogeneic hematopoietic cell transplantation
por: Tian, Linlu, et al.
Publicado: (2022)

Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1
por: Chauhan, Neha, et al.
Publicado: (2016)

Differential Expression of Ormdl Genes in the Islets of Mice and Humans with Obesity
por: Lee, Hugo, et al.
Publicado: (2020)

Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers
por: Zhu, Tengjiao, et al.
Publicado: (2020)

ORMDL1 is upregulated and associated with favorable outcomes in colorectal cancer
por: Wang, Qian, et al.
Publicado: (2021)

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus
por: Acevedo, Nathalie, et al.
Publicado: (2015)

Altered Sphingolipid Metabolism Is Associated With Asthma Phenotype in House Dust Mite-Allergic Patients
por: Kowal, Krzysztof, et al.
Publicado: (2019)

Sepsis-Associated Encephalopathy: The Blood–Brain Barrier and the Sphingolipid Rheostat
por: Kuperberg, Stephen J., et al.
Publicado: (2017)

Sphingolipids and Diagnosis, Prognosis, and Organ Damage in Systemic Lupus Erythematosus
por: Harden, Olivia C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d02gas2a976gifauii0is649oe