Synthetic Lethal Activity of Benzophenanthridine Alkaloids From Zanthoxylum coco Against BRCA1-Deficient Cancer Cells

Several plants from South America show strong antitumoral properties based on anti-proliferative and/or pro-apoptotic activities. In this work we aimed to identify selective cytotoxic compounds that target BRCA1-deficient cancer cells by Synthetic Lethality (SL) induction. Using a high-throughput sc...

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Detalles Bibliográficos
Autores principales: García, Iris A., Pansa, Maria Florencia, Pacciaroni, Adriana Del Valle, García, Manuela E., Gonzalez, Maria Laura, Oberti, Juan Carlos, Bocco, José Luís, Carpinella, Maria Cecilia, Barboza, Gloria E., Nicotra, Viviana E., Soria, Gastón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793782/
https://www.ncbi.nlm.nih.gov/pubmed/33424604
http://dx.doi.org/10.3389/fphar.2020.593845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793782/
https://www.ncbi.nlm.nih.gov/pubmed/33424604
http://dx.doi.org/10.3389/fphar.2020.593845

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