A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity

TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, which play important roles in tumor growth, survival, cell adhesion, as well as innate immunity, phagocytosis, and immune-suppressive activity. Therefore, targeting both AXL and MERTK kinases may directly impact tumor grow...

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Detalles Bibliográficos
Autores principales: Rios-Doria, Jonathan, Favata, Margaret, Lasky, Kerri, Feldman, Patricia, Lo, Yvonne, Yang, Gengjie, Stevens, Christina, Wen, Xiaoming, Sehra, Sarita, Katiyar, Kamna, Liu, Ke, Wynn, Richard, Harris, Jennifer J., Ye, Min, Spitz, Susan, Wang, Xiaozhao, He, Chunhong, Li, Yun-Long, Yao, Wenqing, Covington, Maryanne, Scherle, Peggy, Koblish, Holly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793849/
https://www.ncbi.nlm.nih.gov/pubmed/33425754
http://dx.doi.org/10.3389/fonc.2020.598477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793849/
https://www.ncbi.nlm.nih.gov/pubmed/33425754
http://dx.doi.org/10.3389/fonc.2020.598477

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