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CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells
BACKGROUND: Multiple Myeloma (MM) is a heterogeneous, hematological neoplasm that accounts 2% of all cancers. Although, autologous stem cell transplantation and chemotherapy are currently the most effective therapy, it carries a notable hazards, in addition for being non curative. Recently, the Clus...
Autores principales: | Khaled, Mai, Moustafa, Amr S., El-Khazragy, Nashwa, Ahmed, Maha Imam, Abd Elkhalek, Marwa Ali, El_Salahy, Eman M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794028/ https://www.ncbi.nlm.nih.gov/pubmed/33418558 http://dx.doi.org/10.1371/journal.pone.0245349 |
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