miR299a-5p promotes renal fibrosis by suppressing the antifibrotic actions of follistatin

Caveolin-1 (cav-1), an integral protein of the membrane microdomains caveolae, is required for synthesis of matrix proteins by glomerular mesangial cells (MC). Previously, we demonstrated that the antifibrotic protein follistatin (FST) is transcriptionally upregulated in cav-1 knockout MC and that i...

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Detalles Bibliográficos
Autores principales: Mehta, Neel, Li, Renzhong, Zhang, Dan, Soomro, Asfia, He, Juehua, Zhang, Ivan, MacDonald, Melissa, Gao, Bo, Krepinsky, Joan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794215/
https://www.ncbi.nlm.nih.gov/pubmed/33420269
http://dx.doi.org/10.1038/s41598-020-80199-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794215/
https://www.ncbi.nlm.nih.gov/pubmed/33420269
http://dx.doi.org/10.1038/s41598-020-80199-z

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