Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

Coronaviruses spike (S) glycoproteins mediate viral entry into host cells by binding to host receptors. However, how the S1 subunit undergoes conformational changes for receptor recognition has not been elucidated in Alphacoronavirus. Here, we report the cryo-EM structures of the HCoV-229E S trimer...

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Detalles Bibliográficos
Autores principales: Song, Xiyong, Shi, Yuejun, Ding, Wei, Niu, Tongxin, Sun, Limeng, Tan, Yubei, Chen, Yong, Shi, Jiale, Xiong, Qiqi, Huang, Xiaojun, Xiao, Shaobo, Zhu, Yanping, Cheng, Chongyun, Fu, Zhen F., Liu, Zhi-Jie, Peng, Guiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794242/
https://www.ncbi.nlm.nih.gov/pubmed/33420048
http://dx.doi.org/10.1038/s41467-020-20401-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794242/
https://www.ncbi.nlm.nih.gov/pubmed/33420048
http://dx.doi.org/10.1038/s41467-020-20401-y

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