Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds

Novel bacterial type II topoisomerase inhibitors (NBTIs) stabilize single-strand DNA cleavage breaks by DNA gyrase but their exact mechanism of action has remained hypothetical until now. We have designed a small library of NBTIs with an improved DNA gyrase-binding moiety resulting in low nanomolar...

Descripción completa

Detalles Bibliográficos
Autores principales: Kolarič, Anja, Germe, Thomas, Hrast, Martina, Stevenson, Clare E. M., Lawson, David M., Burton, Nicolas P., Vörös, Judit, Maxwell, Anthony, Minovski, Nikola, Anderluh, Marko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794245/
https://www.ncbi.nlm.nih.gov/pubmed/33420011
http://dx.doi.org/10.1038/s41467-020-20405-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794245/
https://www.ncbi.nlm.nih.gov/pubmed/33420011
http://dx.doi.org/10.1038/s41467-020-20405-8

Ejemplares similares