Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice

Chromosomal instability (CIN) is a hallmark of cancer, leading to aneuploid cells. To study the role that CIN plays in tumor evolution, several mouse models have been engineered over the last 2 decades. These models have unequivocally shown that systemic high-grade CIN is embryonic lethal. We and ot...

Descripción completa

Detalles Bibliográficos
Autores principales: Schukken, Klaske M., Zhu, Yinan, Bakker, Petra L., Koster, Mirjam H., Harkema, Liesbeth, Youssef, Sameh A., de Bruin, Alain, Foijer, Floris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794249/
https://www.ncbi.nlm.nih.gov/pubmed/33420244
http://dx.doi.org/10.1038/s41598-020-80169-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794249/
https://www.ncbi.nlm.nih.gov/pubmed/33420244
http://dx.doi.org/10.1038/s41598-020-80169-5

Ejemplares similares