FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

Focal adhesion kinase (FAK) localizes to focal adhesions and is overexpressed in many cancers. FAK can also translocate to the nucleus, where it binds to, and regulates, several transcription factors, including MBD2, p53 and IL-33, to control gene expression by unknown mechanisms. We have used ATAC-...

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Detalles Bibliográficos
Autores principales: Griffith, Billie G. C., Upstill-Goddard, Rosanna, Brunton, Holly, Grimes, Graeme R., Biankin, Andrew V., Serrels, Bryan, Byron, Adam, Frame, Margaret C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794255/
https://www.ncbi.nlm.nih.gov/pubmed/33420223
http://dx.doi.org/10.1038/s41598-020-80111-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794255/
https://www.ncbi.nlm.nih.gov/pubmed/33420223
http://dx.doi.org/10.1038/s41598-020-80111-9

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