Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes

The long-standing perception of Protein Kinase C (PKC) as a family of oncoproteins has increasingly been challenged by evidence that some PKC isoforms may act as tumor suppressors. To explore the hypothesis that activation, rather than inhibition, of these isoforms is critical for anticancer activit...

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Detalles Bibliográficos
Autores principales: Cullen, Jason K., Boyle, Glen M., Yap, Pei-Yi, Elmlinger, Stefan, Simmons, Jacinta L., Broit, Natasa, Johns, Jenny, Ferguson, Blake, Maslovskaya, Lidia A., Savchenko, Andrei I., Mirzayans, Paul Malek, Porzelle, Achim, Bernhardt, Paul V., Gordon, Victoria A., Reddell, Paul W., Pagani, Alberto, Appendino, Giovanni, Parsons, Peter G., Williams, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794351/
https://www.ncbi.nlm.nih.gov/pubmed/33420238
http://dx.doi.org/10.1038/s41598-020-80397-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794351/
https://www.ncbi.nlm.nih.gov/pubmed/33420238
http://dx.doi.org/10.1038/s41598-020-80397-9

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