Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells

Metabolic reprogramming and its molecular underpinnings are critical to unravel the duality of cancer cell function and chemo-resistance. Here, we use a constraints-based integrated approach to delineate the interplay between metabolism and epigenetics, hardwired in the genome, to shape temozolomide...

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Detalles Bibliográficos
Autores principales: Immanuel, Selva Rupa Christinal, Ghanate, Avinash D., Parmar, Dharmeshkumar S., Yadav, Ritu, Uthup, Riya, Panchagnula, Venkateswarlu, Raghunathan, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794364/
https://www.ncbi.nlm.nih.gov/pubmed/33420045
http://dx.doi.org/10.1038/s41540-020-00161-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794364/
https://www.ncbi.nlm.nih.gov/pubmed/33420045
http://dx.doi.org/10.1038/s41540-020-00161-7

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